In Marvel Comics ’ immense roster of heroes and villain there is n’t a name that can quite liken to Deadpool . Created by Rob Liefeld , the case has evolved to become one of the well comedic characters to ever be created in comic strip . Coming from the geezerhood of “ too many pouches , ” Deadpool did n’t begin as a quippy mercenary , yet what makes the character stand out is his tendencies to unwrap the fourth wall and to crack up a undecomposed joke .

Because of the character ’s healing factor there are so many non - canon comic have been found around the character , in scenario where he has even eliminated the intact Marvel Universe in very intricate and creative way , but that does n’t imply the merc with a lip is unstoppable .

UPDATE: 2022/10/10 15:54 EST BY GEORGE CHRYSOSTOMOU

Deadpool is head to the Marvel Cinematic Universe after years of devotee hop to see that connection made . Since he ’s sure go to be face off against some famous heroes and villain on the crowing projection screen , it feels pretty relevant to pass to the comic Holy Scripture root and investigate who the merc with a rima oris could and could n’t kill .

Loses To

Domino

Whether it ’s the big screenland iteration or that of the comedian , Domino seldom loses . The character has been gifted a mutant power that set aside her to carry incredible luck . No matter what happens she always seems to issue forth out of a situation better than everyone around her .

Deadpool often does n’t believe it ’s even a true tycoon , but it really is , as evidenced in the sequel film . If Deadpool was to go up against Domino in any of her flesh , he plainly would n’t bear a chance . The quality would continue to get the better of him , despite his healing ability . No one can battle fate .

Eternity

Mostcomic Scripture fans sleep with that Deadpoolhas try out to front deities before . Much like the Living Tribunal who will be discussed in further detail , Eternity is one of the most sinewy beings in existence . He ’s a part of the very material and makeup of world .

That stand for that he ’s somewhat unmanageable to defeat . He ’s immortal on another level and if he was to interfere , he could rid beings from every known universe ; unless he was stopped by something like the Infinity Stones . One - on - one , Deadpool is just rubble compared to a being like Eternity .

The Phoenix Force

The Phoenix Force is an entity that no one fully get the picture . It has attached itself to knock-down wedge like Echo and Jean Grey , with very few having the power to really halt its impulse . It both enhances what ’s there and brings a degree of cosmic ability that no one has realize before .

Deadpool is pretty weak against variation like Jean Grey as it is . Pitching him against a divine force like the Phoenix is leading to disaster . The Phoenix Force comprehends being , time , and space on a grade that Deadpool just does n’t operate on on . His very atoms could be part if the fiery beast willed it .

Ghost Rider

There are not many in the Marvel Universe who can defeat the Spirit of Vengeance . He is exceedingly strong , can summon devil , has a penance stare , is immortal , has a super fast cure factor , can tincture objects with hellfire , and can even give portals to different dimensions . Fans have see to it some of these great power transpire on the boastful CRT screen with the Nicolas Cage interpretation of the fiber , but Ghost Rider truly came to life with Gabriel Luna ’s portrayal in season 4 ofAgents of S.H.I.E.L.D. Here , Ghost Rider was also able to transfer his intent into other mortals .

Deadpool is virtually immortal thanks to an array of different factors , but Ghost Rider ’s abilities make out straight from Hell . There are many ways Ghost Rider can spite Deadpool , but one manner he did it in the comics was with the penance stare , which make Deadpool to experience the pain in the neck of those he ’s offend in the past . In typical Deadpool trend , though , he actually enjoyed the pain .

Thanos With The Infinity Gauntlet

There ’s not really much one can do when facing an opponent whose prime ability is to never perish . Hence , Thanos would have no chance against Deadpool if he was face him without the Infinity Gauntlet . Thanos can eradicate full civilizations and pass over out one-half of all life in the universe with a pushover of his finger . That ’s what happened in theInfinity Gauntletcomic run away by Jim Starlin . With so much power and myriad control over reality , Thanos is unstoppable . That ’s why Deadpool would certainly bite the dust if he defy face Thanos with his marvelous mitt .

Thanos could simply wish that Deadpool had never subsist and he would win right away . Likewise , Thanos could change realism and erase Deadpool ’s healing factor from his eubstance , making the merc with a mouth as vulnerable as a simple somebody . The Titan , though , is an honorable psychopath , so he would in spades permit Deadpool have his fun before in the end defeating him . This has happened in the comics , when Thanos sprain Deadpool into a pile of guck .

The Hulk

Though his cinematic counterpart played by Mark Ruffalo is nothing like the Hulk in the comics , the MCU ’s Jade Giant can still wad a punch . He ’s faced god from other attribute and even Asgardian mythological creatures . Yet , comic book Hulk is one hundred times more incredible . This Hulk even rip Wolverine in half in one comic book plot line . ThePlanet HulkandWorld - Breaker Hulkstorylines saw the Jade Giant almost completely obliterating all the Marvel torpedo , even the Sentry . The Hulk is one character Deadpool ca n’t beat .

The Hulk and Deadpool faced each other in a non - canon comic . Here , Deadpool went crazy and set about pass superheroes and supervillains until there were none left . Yet , Deadpool could n’t defeat Hulk and there was even an instant where Hulk utterly dismember Deadpool . The only way the Merc with a Mouthwas able to get the upper hand was by not eliminating the Hulk , but instead terminating Bruce Banner .

MCU Thor

Thor ’s speciality really got an upgrade in his third film , where if it was n’t for the Grandmaster , Thor would have defeated the Incredible Hulk well . While Thor ’s power regressed a fiddling second inAvengers : Infinity War , he ’s still immensely powerful . He is slightly the same in the comics , so if Deadpool ever face Thor , the god of thunder would have the winning edge .

It ’s true that Deadpool bring off to terminate Thor using Pym Particles in a non - canon comic by magnify Mjolnir . But MCU Thor never needed Mjolnir in the first property . The pounding was just a gimmick that suppressed and helped Thor control his office , according to Odin .

If Deadpool ever tried that whoremaster again on MCU Thor , the results would n’t be the same . Their fight would probably last an implausibly long clock time , but in the close , even immortals get tired .

Ben Affleck as Christian drumming his hand on the table while talking to Cynthia Addai-Robinson’s Marybeth in The Accountant 2

One Punch Man

First published in 2009,One - Punch Manquickly went viral in 2012 due to its satiric nature in critiquing the superhero genre . The webcomic was later made into an anime . As his name inculpate , One - Punch Man can defeat any opponent with just one punch , though , at time , some opponents go down with two . The general consensus is that One - Punch Man can defeat just about anybody . This is primarily because Saitama serves as a satiric take on the superhero .

This is definitely a fight that go great on composition and on practice session . Saitamacould defeat Deadpool with one puncher , but then Deadpool would bring around and come back to life . It ’s possible that Saitama could perforate Deadpool so arduous that his healing factor would survey to vanish , leaving the Merc with a Mouth as vulnerable as a fruit fly .

The Living Tribunal

There are many powerful theatrical role in the realm of Marvel , but none can compare to the might of the Living Tribunal . He is only bested by the One Above All , who at fourth dimension is presented as being the fabled comic book artist Jack Kirby . The Living Tribunal could might as well be view omnipotent . His abilities include near - omniscience and reality warp , as well as ubiquity .

Alas , not even Deadpool with the combined capabilities of X - Force can bring the Living Tribunal to submission . The Tribunal could falsify world and defeat Deadpool in a matter of seconds - either by wishing Deadpool ’s healing ingredient away or by erasing him from being . As the name imply , the Living Tribunal is a cosmic judge , so he would first put Deadpool on trial . With all the crazy thing Deadpool has done , it ’s no question the Living Tribunal ’s verdict would n’t be at all lenient .

Lady Chaos

Mistress Death , also known as Lady Chaos , has had a long history with Deadpool . Their romance go as far as including Thanos into the commixture . What makes Deadpool and Lady Chaos ’s wild-eyed connection rather amusing and a piffling wry is that Deadpool is a military personnel who ca n’t give-up the ghost . As the personification of the opposite of life sentence in the Marvel Universe , Lady Chaos has innumerable powers which admit dimensional manipulation , cosmic awareness , invulnerability , immortality , and the ability to add people back from the hereafter . For this and many other reason , Deadpool would lose to the love of his life .

Deadpool loves Lady Chaos so much that if they ever got in a physical battle his lovemaking for her would n’t allow him to strike a single kick . Plus , even if a competitiveness result , the entity would easily defeat Deadpool in a issue of seconds . She could easy distort reality and wish Deadpool ’s power away , or wish him out of existence , even though that ’s not how she ordinarily roles .

Can Defeat

The Sentry

The Sentry is essentially Marvel ’s Superman . Deadpool could probably kill Supes eventually if he keep on to regenerate again and again . lookout should be easy to get the better of as there ’s a paradox to the character , with an interior struggle between Sentry and his darker side : The Void .

Deadpool know all too well about the danger of an internal battle and could take advantage of that instability . If Sentry and Deadpool were to face off in one on one combat , Sentry would eventually lose , as he has done in the funnies multiple times .

Kingpin

The Kingpin of offense is more likely to lease Deadpool to assassinate someone than he is to come to blow with the merc . He understands how dangerous the mutant really is and has often elected to stick far away from the brand - wielding menace . Kingpin has baron in the contour of money and resourcefulness .

But unless he pays Deadpool off , he might not be capable to counter Wade Wilson in combat for long . He has physical strength and has combat the like of Elektra in the comics , but Deadpool can just keep going . Kingpin has been shown to tire easily , especially once his rage pass .

Groot

Groot come from a race of beingness that resemble plant life and has an incredible raiment of superpowers . He can control plant life in any planet , as well as make himself heavy or smaller calculate on the situation . Due to his capacity to regrow limbs and even altogether regrow himself after perishing , Groot partake in many similarities with Deadpool . Both are technically immortal , the only difference being that Groot ’s cure ability take a lot more time to bring in . The comic al-Qur’an version of Groot trace the same set of rules as MCU Groot , but this Groot is a fleck more powerful . all the same , Deadpool could easily defeat him .

In realness , any version of Deadpoolwould probably have way too much fun figure out how Groot procedure to try out and finish the alien . That ’s just the kind of person Deadpool is . But if the two ever got in a fight to the end , Deadpool would have the edge due to his fast healing factor . Groot would obviously regrow akin to his reincarnation in 2014’sGuardians of the Galaxy , but it would take such a farseeing time that Deadpool would ’ve already crowned himself the success .

Thanos Without The Infinity Gauntlet

Thanos and the Merc with a Mouth have history together , and not the good kind . They ’ve been in myriad fights , trying to one - up each other on every individual case , but nothing comes tight to the rather awkward love triangle between the two Marvel quality and Lady Death . Only one lucky fellow can gain a lucky lady ’s heart . This time around , that lucky swain would in spades be Deadpool - but only if Thanos was n’t wielding the Infinity Gauntlet .

It ’s been proven to be a difficult task to overcome the brainsick Titan Thanos in the comics . The character has even annihilate the entire Marvel Universe before . Deadpool has also done such a deed , but mark them both in a real fight to the last and Deadpool will stand triumphant . Deadpool has the sumptuosity of life never pass on his calamitous body . Thanos would probably annihilate Deadpool over and over , but with the merc ’s regenerative power it would only be a matter of time until Deadpool strikes the net blow and advance this bout .

The X-Men

TheX - Men have essay to comprise Deadpoolinto their team many clock time . He has finally fall in up in the comics , but it was still a running jest in the firstDeadpoolmovie . Colossus saw Deadpool as the perfect campaigner to bring together the superhero ensemble , but Deadpool , of course , had other plans . There have been many time when Deadpool and the go - Men have traded slug , but none compare to when Deadpool terminated all of them in a non - canon comic . In that comic , Deadpool takes out the bulk of the X - Men , end with Wolverine .

To halt Logan from healing , Deadpool hit him with a special type of weapon that conquer his heal factor and the destroy him . This was all before Colossus , Gambit , Rogue , Cyclops , Emma Frost , and others perish by means of Deadpool . Since the cinematic Deadpool be given to accompany the same concept as funny Bible Deadpool , it ’s possible that the Merc with a Mouth could actually bring the entire Fox X - Men roster to its knees .

Loki

Loki is one of those fictitious character who is unmanageable to vote down no topic the circumstances . Loki is able to shapeshift and become impalpable , meaning that if he ’s terminate by a character , who ’s to say that was really Loki in the first situation ? That ’s what happen inThor : The Dark Worldwhen Thor saw his brother perish , when in fact Loki fake his own dying and was now masquerade as Odin on Asgard ’s throne . Loki has many more tricks up his mischievous sleeve , like that one prison term he turned Thor into a Gaul , but that does n’t think of Deadpool has no chance against the god of mischief .

In one of Marvel Comics ’ most beast panels , Deadpool used the head of Medusa to turn Loki , Hercules , Valkyrie , and a number of other gods into gemstone . But this is not the only mode Deadpool could defeat Loki . The god of mischief is a heavy user of magic , but sometimes Deadpool has shown to be invulnerable to wizardly spells .

Doctor Strange

Doctor Strange has been shown to be so knock-down that Marvel has been forced to take his might levels down a few pass in the comics . There was a clip he faced Galactus channelize on and won , and then a time when he even challenged Eternity and the Living Tribunal . latterly , though , while Doctor Strange is still a very herculean sorcerer , he has n’t been as godlike as his ‘ seventy counterpart . In the MCU , Doctor Strange is now just becoming as powerful . He was able to harbour his own against Thanos , who had in his Infinity Gauntlet the Soul , Power , Space and Reality Stone .

AfterDeadpool eliminates Spider - Man , the X - Men , and Wolverine , a non - canon comic evince us a panel of Doctor Strange getting stabbed and buy the farm in the process . While it was n’t really cleared how the Merc with a Mouth deal to do this , Deadpool seemingly displace Doctor Strange in the Sanctum Sanctorum . There are many ways the MCU version of Doctor Strange could avoid a frustration from Deadpool . A passably obvious one is by ferment back time , but in the aforementioned non - canon comedian , Strange regrettably had a different case of Eye of Agamotto .

Galactus

Galactus has been defeated many times before by heroes such as the Fantastic Four , The Avengers , and Franklin Richards , so it ’s not unlikely that Deadpool could do the same . Especially since Deadpool is virtually immortal and Galactus has one very specific failing .

Galactus get weaker and weak the longer he go without consume a planet . It ’s an easy bet that Deadpool would use that to his reward . Galactus could obliterate Deadpool a million times , but the Merc with a Mouth will total back every metre to inflict a little more harm .

There was one meter in the comic when Deadpool face Galactus head on , and somehow won . Instead of slice the giant to pieces or punching through his heart , Deadpool just talked and talked - and talked . Indeed , Galactus get so annoyed by Deadpool ’s quips that he finally give up .

How Rachel Zegler’s

Uatu The Watcher

Uatu the Watcher belongs to a group of celestial beingness known as the Watchers . They pledge an oath to only observe , platter and never step in in any planetary amour , but Earth ’s Uatu is not one to follow such rules . Indeed , Uatu has interfere many sentence before in the Marvel Comics page , especially when Galactus determine that Earth would be his next repast . What ’s singular about Uatu and the Watchers is that they themselves own unbelievable powers and abilities . Uatu , in particular , has an array of cosmic major power and superhuman intelligence service . At times he has even been show up to be immortal , but that all changed when he faced Deadpool .

In a non - canon comic , beforeRob Liefield ’s Deadpool managedto obviate the intact Marvel Universe , he was able to single - handedly licking Uatu the Watcher , who at that point in that comedian was narrating the narration . Deadpool acquired an artefact called a God - Taser and after using it against Uatu , the Merc with a Mouth follow to take the Watcher ’s life away .

The Avengers

Earth ’s mighty heroes have face a numeral of dangerous enemies , each prison term find a mode to save the Earth from impending doomsday and destruction . While the same ca n’t be say for the MCU Avengers give their recent installation , they are still Earth ’s best Bob Hope for survival . Indeed , the Avengers will protect Earth until their last breath , but who will protect the Avengers when Deadpool comes around ? Deadpool proved to be the team ’s most difficult opponent , because he destroyed them all in one of the most popular non - canon comics from Marvel .

Not a individual member of the Avengers survived the onslaught . The approach was so macabre that Captain America was even slice in half by his own vibranium cuticle . Thor got it worse with Mjolnir smashing his grimace . Poor Hawkeye was n’t even able to take out his obeisance and pointer . Like in the movies , Clint should ’ve just retire .

NEXT:10 Best Antiheroes In Marvel Comics

Sidious, Tyranus, Maul, and Vader.

Split image of thor, Deadpool, and Thanos Marvel feature

Domino in X-Force

Infinity and Eternity stand together in a Marvel comic

Phoenix Force Amber Hunt

Ghost Rider defeats Deadpool

Deadpool vs Thanos

Deadpool fights the Hulk

Thor Ragnarok Infinity War

Saitama standing with his arms crossed in One Punch Man

The Living Tribunal wears a purple headdress as it floats in space in Marvel Comics.

Marvel comics Deadpool and Death

The Sentry unleashes his powers

Marvel Kingpin Comic Good Guy

Deadpool fights Hawkeye as Rocket and Groot look on in Marvel Comics.

Thanos chasing Deadpool, who stole the Infinity Gauntlet

Deadpool 2 Trailer Colossus Butt Grab

Deadpool turns Loki to stone

Doctor Strange Using The Darkhold

Deadpool annoys Galactus

Deadpool eliminates Uatu

Deadpool and The Avengers

Movies

Deadpool